On Jun 25, 12:33*am, Mark Thorson > wrote:
> Cheryl wrote:
>
> > I take Turmeric supplements.
>
> Curcumin (the yellow pigment in tumeric) both inhibits
> P-glycoprotein (the cell membrane protein that transports
> toxins out of the cell) and activates the steroid and
> xenobiotic receptor (SXR). *In the short term, it inhibits
> the clearance of toxins and drugs. *In the long term,
> it activates at the transcriptional level greater
> expression of the xenobiotic transporter P-gp and the
> main metabolizing enzyme in the human body CYP3A4.
> Oooh! *You don't want that!
>
> That's why I stopped eating curry completely a few years
> ago. *If I was ever diagnosed with cancer, I might
> already be in a state of multidrug resistance (up-regulation
> of expression of drug clearance enzymes), if I continued
> the high level of curry consumption I had for many years.
>
> That's also why I stopped eating Chinese chives. *They
> contain another modulator of drug clearance.
>
> Those aren't the only foods that mess around with drug
> clearance. *Yellow onions and grapefruit also do that.

Grapefruit almost killed someone I know by interfering with clearance
of a blood pressure medication.

--Bryan