On Jun 25, 7:26*am, Food Snob® > wrote:
> On Jun 25, 12:33*am, Mark Thorson > wrote:
>
>
>
> > Cheryl wrote:
>
> > > I take Turmeric supplements.
>
> > Curcumin (the yellow pigment in tumeric) both inhibits
> > P-glycoprotein (the cell membrane protein that transports
> > toxins out of the cell) and activates the steroid and
> > xenobiotic receptor (SXR). *In the short term, it inhibits
> > the clearance of toxins and drugs. *In the long term,
> > it activates at the transcriptional level greater
> > expression of the xenobiotic transporter P-gp and the
> > main metabolizing enzyme in the human body CYP3A4.
> > Oooh! *You don't want that!
>
> > That's why I stopped eating curry completely a few years
> > ago. *If I was ever diagnosed with cancer, I might
> > already be in a state of multidrug resistance (up-regulation
> > of expression of drug clearance enzymes), if I continued
> > the high level of curry consumption I had for many years.
>
> > That's also why I stopped eating Chinese chives. *They
> > contain another modulator of drug clearance.
>
> > Those aren't the only foods that mess around with drug
> > clearance. *Yellow onions and grapefruit also do that.
>
> Grapefruit almost killed someone I know by interfering with clearance
> of a blood pressure medication.
>
> --Bryan

Grapefruits are weird. They interact with a LOT of medications.

John Kuthe...