No, you have it exactly wrong. Acetic acid CH3-COOH can be converted
directly to acetyl-CoA via the enzyme acetate thiokinase (costing
hydrolysis of one ATP in the process) and from there it feeds the 2
carbon group directly into the citric acid cycle, where it is oxidized
to CO2 and water, as I said. No acid-base chemistry is involved. No
acid or base load to the body is involved, other than the temporary
need to get rid of the CO2, which of course happens in the lungs, not
the urine.
Now, if you give somebody the acetate salt of a metal (sodium acetate,
say) then you have an effective alkaline load which costs one unit of
mineral acid to get rid of. And this does involve the kidneys. Or, if
you prefer to look at it that way, it allows the body to get rid of one
unit of the kinds of mineral acids it's always making from protein and
DNA oxidation (sulfuric acid, phosphoric acid). So if you give somebody
sodium acetate (or citrate or lactate or any organic acid salt) the
urine will become more alkaline than it would be otherwise. But if you
give the organic acids themselves (acidic, lactic, citric acid) nothing
whatsoever happens to the urine pH. These are burned to CO2 and water,
and that's the end of it.
Got it?
SBH
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