I've found no problem in switching between High and Low Crock-Pot
settings at a rate of 1:2.
That is, any combination seems to yield the same results.... so, for
your 8-10 hour (low) cooking, you can do it on high for 4-5 hours or
low for 8-10 hours, or two hours high and 4 low, or 1 high and 6 low.
Just be sure to remember to flip the switch when it's time to.
Scrooge