Where did you learn to spell all of those big words.
Probably sitting on your rectum.
You might try eating them instead of stuffing them up your
rear.

Mark Thorson wrote:

> arossi wrote:
>
> > Has anyone got a recipe for making salted Roasted Whole Peanuts?
>
> Here is a good reason NOT TO EAT PEANUTS.
>
> In this study, 10 out of 36 participants were found to be
> positive for the Thomsen-Friedenreich antigen, which
> causes the cells of their rectum to divide rapidly (possible
> risk factor for colorectal cancer) when they eat peanuts.
>
> Gastroenterology 1998 Jan;114(1):44-9
> Peanut ingestion increases rectal proliferation in individuals
> with mucosal expression of peanut lectin receptor.
> Ryder SD, Jacyna MR, Levi AJ, Rizzi PM, Rhodes JM.
> Department of Gastroenterology, Northwick Park Hospital,
> Middlesex, England.
>
> BACKGROUND & AIMS: The Thomsen-Friedenreich
> blood group antigen (galactose beta 1,3-N-acetyl
> galactosamine alpha-) acts as an oncofetal antigen
> in the colonic epithelium, with low expression in
> normal adult epithelia but increasing to fetal levels
> of expression in hyperplasia or malignancy. Peanut
> lectin is one of the commonest dietary lectins that
> binds this antigen. The aim of this study was to
> determine whether peanut ingestion can alter rectal
> epithelial proliferation.
>
> METHODS: Thirty-six patients with normal colonic
> mucosa consumed 100 g of peanuts each
> day for 5 days. Rectal mitotic index was measured
> before and after ingestion, and changes in
> proliferation were correlated with immunohistochemical
> detection of lectin receptor expression by
> colonocytes and fecal lectin activity as measured
> by hemagglutination assay.
>
> RESULTS: Peanut ingestion caused a 41% increase
> in rectal mucosal proliferation in individuals with
> macroscopically normal mucosa who express
> TF antigen in their rectal mucosae (10 of 36
> patients studied). The proliferative response
> correlated with fecal hemagglutinating activity, and
> peanut lectin could be shown immunohistochemically
> within the rectal mucosa.
>
> CONCLUSIONS: The common expression
> of galactose beta 1,3-N-acetyl galactosamine
> alpha- by hyperplastic and neoplastic epithelia
> may therefore be functionally important because it
> allows interaction with mitogenic dietary lectins.
> This could be an important mechanism for the
> association between diet and colorectal cancer.