was "Baked beans"
x-posted to afd asd mhd
"On Sat, 10 Feb 2007 11:48:11 -0500, Susan
> wrote (quoting Jenny):
<snip>
>
>Catherine E. Gleason, Michael Gonzalez, Jamie S. Harmon, and R. Paul
>Robertson. Determinants of glucose toxicity and its reversibility in
>pancreatic islet Beta-cell line, HIT-T15. Am J Physiol Endocrinol Metab
>279: E997-E1002, 2000
>
>http://ajpendo.physiology.org/cgi/co...act/279/5/E997
>
That's a really interesting paper. It's specifically
interested in beta-cell damage and recovery, not other
damage that may occur to the body from spikes.
For that specific area, they are quite clear that prolonged
exposure causes irreversible damage. One thing I liked was
the grounds for hope of reversibility of damage to the
pancreas with "meticulous glycemic control".
Well worth another read through the summary.
"In summary, these findings indicate that glucose
toxicity of the b-cell is a continuous rather than a
threshold function of glucose concentration and that
the shorter the period of antecedent glucose toxicity,
the greater the degree of recovery.
Findings from experiments such as these, in conjunction with
many findings published by other researchers (13, 512,
1524, 29, 31, 3436, 38, 39), suggest that abnormally
elevated glucose concentrations in the b-cells environment
can cause a spectrum of changes. With short term
exposure to high glucose concentrations, decreases
in insulin secretion and insulin content can
occur that are reversible upon return to normal glucose
concentrations. The term glucose desensitization
seems most apt to describe this sequence of events (16).
On the other hand, a spectrum of pathophysiological
changes may occur with more prolonged exposure of
the b-cell to supraphysiological glucose concentrations.
Using various experimental models, many researchers
have described adverse effects of glucose on b-cell function
by the term b-cell exhaustion. The distinction
between b-cell exhaustion and glucose toxicity is not
always clear. We favor the concept that the two may be
in a pathophysiological continuum (32). In this context,
b-cell exhaustion might be earlier and more likely to be
reversible, whereas glucose toxicity is later and less
likely to be reversible.
In this context, it seems likely that early, effective
management by diet and drugs of hyperglycemia in type 2
diabetes is an important aspect of preserving residual
b-cell function. The same argument for meticulous glycemic
control can be made after pancreas or islet
transplantation."
Another logical justification for Jennifer's "Test, test,
test".
I will still avoid short-term spikes as well as the
long-term elevated BG levels.
Cheers, Alan, T2, Australia.
d&e, metformin 1000mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com/
http://loraltravel.blogspot.com/
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