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General Cooking (rec.food.cooking) For general food and cooking discussion. Foods of all kinds, food procurement, cooking methods and techniques, eating, etc. |
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Cheryl wrote:
> > I take Turmeric supplements. Curcumin (the yellow pigment in tumeric) both inhibits P-glycoprotein (the cell membrane protein that transports toxins out of the cell) and activates the steroid and xenobiotic receptor (SXR). In the short term, it inhibits the clearance of toxins and drugs. In the long term, it activates at the transcriptional level greater expression of the xenobiotic transporter P-gp and the main metabolizing enzyme in the human body CYP3A4. Oooh! You don't want that! That's why I stopped eating curry completely a few years ago. If I was ever diagnosed with cancer, I might already be in a state of multidrug resistance (up-regulation of expression of drug clearance enzymes), if I continued the high level of curry consumption I had for many years. That's also why I stopped eating Chinese chives. They contain another modulator of drug clearance. Those aren't the only foods that mess around with drug clearance. Yellow onions and grapefruit also do that. If you're on cancer chemotherapy or a recipient of an organ transplant (and taking the anti-rejection drug cyclosporine), you'll probably be given a list of foods to avoid. Any complete list will contain all of the foods I mentioned above, plus some herbal remedies such as St. John's Wort. SJW has caused organ rejection in some people, and failure of birth control drugs in other people because of its powerful up-regulation of the drug clearance enzymes. |
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