On Jun 24, 10:33*pm, Mark Thorson > wrote:
> Cheryl wrote:
>
> > I take Turmeric supplements.
>
> Curcumin (the yellow pigment in tumeric) both inhibits
> P-glycoprotein (the cell membrane protein that transports
> toxins out of the cell) and activates the steroid and
> xenobiotic receptor (SXR). *In the short term, it inhibits
> the clearance of toxins and drugs. *In the long term,
> it activates at the transcriptional level greater
> expression of the xenobiotic transporter P-gp and the
> main metabolizing enzyme in the human body CYP3A4.
> Oooh! *You don't want that!
>
> That's why I stopped eating curry completely a few years
> ago. *If I was ever diagnosed with cancer, I might
> already be in a state of multidrug resistance (up-regulation
> of expression of drug clearance enzymes), if I continued
> the high level of curry consumption I had for many years.
>
> That's also why I stopped eating Chinese chives. *They
> contain another modulator of drug clearance.
>
> Those aren't the only foods that mess around with drug
> clearance. *Yellow onions and grapefruit also do that.
> If you're on cancer chemotherapy or a recipient of
> an organ transplant (and taking the anti-rejection drug
> cyclosporine), you'll probably be given a list of foods
> to avoid. *Any complete list will contain all of the
> foods I mentioned above, plus some herbal remedies such
> as St. John's Wort. *SJW has caused organ rejection in
> some people, and failure of birth control drugs in other
> people because of its powerful up-regulation of the drug
> clearance enzymes.

Hey Mark......I'm certain that, if you look long enough and hard
enough at any particular component of any particular food you can find
a toxin that can possibly do harm.

Personally I don't focus on the possibility of harm simply because of
all these 'studies'. By the time you've obsessesd about all of them
you are down to air and water and both have toxins in them that can
kill you.

All things in moderation. I don't believe anyone eats the amount of
any particular food on a continuous basis that can actually cause the
conditions found in these studies.

Seriously, take a couple of steps back and look at the big picture.
Just sayin.......... ;-)