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General Cooking (rec.food.cooking) For general food and cooking discussion. Foods of all kinds, food procurement, cooking methods and techniques, eating, etc. |
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On Jun 25, 7:26*am, Food Snob® > wrote:
> On Jun 25, 12:33*am, Mark Thorson > wrote: > > > > > Cheryl wrote: > > > > I take Turmeric supplements. > > > Curcumin (the yellow pigment in tumeric) both inhibits > > P-glycoprotein (the cell membrane protein that transports > > toxins out of the cell) and activates the steroid and > > xenobiotic receptor (SXR). *In the short term, it inhibits > > the clearance of toxins and drugs. *In the long term, > > it activates at the transcriptional level greater > > expression of the xenobiotic transporter P-gp and the > > main metabolizing enzyme in the human body CYP3A4. > > Oooh! *You don't want that! > > > That's why I stopped eating curry completely a few years > > ago. *If I was ever diagnosed with cancer, I might > > already be in a state of multidrug resistance (up-regulation > > of expression of drug clearance enzymes), if I continued > > the high level of curry consumption I had for many years. > > > That's also why I stopped eating Chinese chives. *They > > contain another modulator of drug clearance. > > > Those aren't the only foods that mess around with drug > > clearance. *Yellow onions and grapefruit also do that. > > Grapefruit almost killed someone I know by interfering with clearance > of a blood pressure medication. > > --Bryan Grapefruits are weird. They interact with a LOT of medications. John Kuthe... |
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